84-1082-45　［取扱停止］Glucagon-like Peptide 2 Receptor (GLP2R) 100ug　G2040-39E

特徴

• Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide.
• The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2.
• The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis.
• The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration.
• GLP2 Receptor, a 550aa protein in rat, 553aa in human (chr 17p13.3), serves as receptor for GLP2.
• The activity of this receptor is mediated by G proteins which activate the adenylyl cyclase.
• GLP2 Receptor is mainly expressed in gut, and closely related to the receptor for GLP1.
• Applications:Suitable for use in Western Blot and ELISA .
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1-10ug/ml, using Chemiluminescence technique
• ELISA: 1:10,000-1:100,000 use 50-100ng/ml control peptide/well
• Optimal dilutions to be determined by researcher.
• Control Peptide:G2040-39F
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage, store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.