84-1082-43　Glucagon-like Peptide 1 Receptor (GLP1R) 50ug　G2040-38D

特徴

• Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide.
• The glucagon precursor contains 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2.
• The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis.
• The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration
• GLP1 Receptor is a 489aa peptide in mouse, 463aa in rat and human (chr 6p21).
• It serves as receptor for GLP1.
• The activity of this receptor is mediated by G protein which activate adenylyl cyclase.
• GLP1 Receptor is mainly expressed in pancreatic islets, stomach and lung.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1-10ug/ml using Chemiluminescence techniqueELISA: 1:10,000-1:100,000.
• Using 50-100ng of control peptide/wellOptimal dilutions to be determined by the researcher.
• Recommended Control Peptide:G2040-38E: Glucagon-like Peptide 1 Receptor, Mouse, Control Peptide
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.