84-1082-11　C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1) (HRP) 100ul　C7907-15C

特徴

• Pentraxins family of proteins acquired the name from their ability to form pentameric (or decameric) structures formed by non-covalent interactions.
• C-reactive protein (CRP or PTX1; mature chain 206 aa; chromosome 1q21-23) nonglycosylated, ~24kD monomer and ~118kD pentamer) is a ubiquitous protein found in both vertebrates and invertebrates.
• Originally CRP was defined as a substance, observed in the plasma of patients with acute infections, that reacted with the C polysaccharide of the pneumococcus.
• It is one of the plasma proteins that are called acute phase reactants because of a pronounced rise in concentration after tissue injury or inflammation; in the case of CRP the rise may be 1000-fold or more.
• CRP is composed of 5 identical, 21,500-molecular weight subunits.
• It is detectable on the surface of about 4% of normal peripheral blood lymphocytes.
• Acute phase reactant CRP is produced in the liver; those cells produce CRP detectable on lymphocytes.
• Applications:Western Blot: 1:1000-1:10,000ELISA: 1:10,000-1:50,000
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O or PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.