84-1081-08　Protein Gene Product 9.5 (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin Thiolesterase, PARK5) 50ul　P9102-70G

特徴

• PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25kD.
• It is present in neurons and in cells of the diffuse neuroendocrine system.
• PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme.
• This enzyme is also known as UCH-L1.
• Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
• It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease.
• Interestingly a common allelic variant of UCH-L1, the S18Y polymorphism is actually protective against Parkinson's disease.
• It is also a marker for cells of the diffuse neuroendocrine system and their tumors.
• Applications:Suitable for use in Immunohistochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry: 1:500-1:1000Western Blot: 1:1000-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.