84-1080-53　TL1A (TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15) 100ug　T8038-08

特徴

• Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis.
• DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) (1-5) is preferentially expressed by T lymphocytes and upregulated during T cell activation.
• The ligand for DR3 was recently identified and designated TL1A (6).
• TL1A also binds decoy receptor DcR3/TR6 (7,8), which is expressed in several lung and colon carcinomas and in some normal tissues.
• TL1A induces apoptosis and NF-κB activation in DR3 expressing cells, which is antagonized by DcR3.
• TL1A is upregulated by proinflammatory cytokines TNF and IL-1.
• TL1A is a longer variant of TL1 (also called VEGI).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-1ug’mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.