Metabotropic glutamate receptors are G-protein coupled receptors activated by glutamate.
Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8.
mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells.
mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500Immunohistochemistry: 1:250Immunocytochemistry: 1:250Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Specificity：Recognizes residues 860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to aa860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein. Species Sequence Homology: human and mouse; 100%; conserved between mGluR2 and mGluR3.
