84-1079-79　Bone Morphogenic Protein Receptor 1A (CD292, BMPR-1A, Bone Morphogenetic Protein Receptor Type IA, Serine Threonine Protein Kinase Receptor R5, SKR5, Activin Receptor-like Kinase 3, ALK-3, ACVRLK3) 200ul　B2553-60B

特徴

• The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2.
• These receptors are also closely related to the activin receptors, ACVR1 and ACVR2.
• The ligands of these receptors are members of the TGF-beta superfamily.
• TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55kD and type II receptors of about 70-80kD.
• Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000Western Blot: 1:100-1:500 to detect BMPR1A in Hela cell lysate
• Immunohistochemistry: 1:50-1:100.
• Formalin-fixed and paraffin-embedded human cancer tissue was stained with B2553-60B followed by peroxidase-conjugate secondary antibody and DAB staining
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.