84-1079-45　［取扱停止］Prostaglandin D Synthase, Hematopoietic form (PGD Synthase) 200ul　P9053-25K

特徴

• Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2.
• PGD2 induces sleep, regulates nociception, inhibits platelet aggregation and acts as an allergic mediator.
• Two distinct types of PGD synthase have been identified, namely the lipocalin-type enzyme (beta-trace) and the hematopoietic enzyme.1,2,3 Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart.
• This enzyme has been identified as beta-trace, which is a major protein in human cerebrospinal fluid.4,2 Hematopoietic PGD synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes.1 This enzyme, which requires glutathione for activity, belongs to the sigma-class of Glutathione-S- Transferases and is approximately 23kD in size.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:200 1 hr at RT or 1:500 with overnight incubation at 4ºC Immunohistochemistry: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.