Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family.
Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors.
Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs.
Furin and other PC family members share structural similarities which include a heterogeneous ~10kD amino-terminal proregion, a highly conserved ~55kD subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence.
These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment.
Furin is the only known PC to possess a transmembrane domain.
Applications:Suitable for use in ELISA, Western Blot and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Immunoprecipitation: 1:500Western Blot: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1Ea
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid. No preservative added.
Specificity：Recognizes human furin convertase and pre-pro-furin convertase.
Isotype：IgG
Calc Applications Abbrev：IP WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa187-198 of human preprofurin convertase.
