The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha (PPARA) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity.
ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G proteincoupled receptors (GPCRs).
The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 amino acids (with a predicted MW of 42.4 kD).
Human and mouse ADIPOR1 have 96.8% homology.
ADIPOR1 has high-affinity receptor for globular adiponectin (gACRP30) but low-affinity receptor for full-length adiponectin.
ADIPOR1 is widely expressed.
It is highly expressed in skeletal muscle.
It is expressed at intermediate levels in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
It is weakly expressed in colon, thymus and small intestine.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications have not been tested.
Recommended Dilutions:Western Blot: 1:1000Immunohistochemistry (paraffin sections): 1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Neat serum
Form：Supplied as a liquid.
Specificity：Recognizes human AdipoR1.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa2-36 SSHKGSVVAQGNGAPASNREADTVELAELGPLLEE of human adiponectin receptor 1 (AdipoR1).
