SLPI is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G.
It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages.
In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities.
These appear to be independent of its ability to inhibit PMN serine proteinases.
SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung.
Another possible role for SLPI is inhibition of protein-disulfide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).
Applications:Suitable for use in Western Blot, ELISA and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Western Blot: 1:10Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
Specificity：Recognizes human secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease or ALP).
