This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood.This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus.
It functions as a chemoattractant, and is also a potent angiogenic factor.
IL8 attracts neutrophils, basophils, and T-cells, but not monocytes.
Cystic fibrosis (CF) is characterized by severe lung inflammation.
The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Applications:Suitable for use in ELISA, Western Blot, Immunoprecipitation and Bioassays.
Other applications not tested.
Recommended Dilution:Western Blot: 1:5Immunoprecipitation: 1:5Bioassays: Must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added.
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.1% BSA.
Specificity：Recognizes natural and recombinant human Interleukin-8 (IL-8). Species Crossreactivity: monkey. Crossreacts with rhesus and cynomolgous natural IL-8.
