ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system.
ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity.
ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.
A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): requires antigen retrieval using heat treatment prior to staining of paraffin sections
Optimal dilution determined by the researcher.
Recommended Secondary Reagents:Sheep anti rabbit IgG: HRP
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Specificity：Recognizes human Angiotensin-converting enzyme 2 (ACE2).
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
