84-1075-56　Syndecan 2 100ug　S9111-40B

特徴

• Syndecans are heparan sulfate proteoglycans that consist of a hydrophobic membrane-spanning domain, a short cytoplasmic domain, and an extracellular domain.
• Syndecans contain a small core protein with distinct functional domains to which multiple glycosaminoglycan chains are linked, predominantly of the heparan sulfate variety.
• Syndecans are involved in cell adhesion, tissue morphogenesis and differentiation and regulation of cell responsiveness to soluble growth-regulatory compounds.
• These functions are attributed primarily to the glycan moieties.
• Syndecans also interact with growth factors such as fibroblast growth factor and epidermal growth factor.
• Syndecan 2 was originally cloned from embryonic fibroblasts.
• Syndecan 2 is expressed in epithelial-mesenchymal interfaces, and prechondrogenic and preosteogenic mesenchymal condensations, which are areas of high morphogenetic activity.
• Syndecan 2 is involved in the mitogenic activity and signaling of Granulocyte-Macrophage Colony-stimulating factor in osteoblasts, and has been shown to have a regulatory role in matrix assembly.
• Increased Syndecan 2 expression is important for colon carcinoma behavior, and Syndecan 2 regulates tumorgenic activity by regulating adhesion and proliferation in colon carcinoma cells.
• Applications:Suitable for use in Immunofluorescence/Immunocytochemistry, Western Blot, Immunohistochemistry, and ELISA.
• Other applications have not been tested.
• Recommended Dilutions:Western Blot: 1:100-1:500Immunohistochemistry (Paraffin): 1:10-1:100Immunofluorescence (IC): 1:100-1500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.