84-1075-24　IRAK 4 (IL-1 Receptor Associate Kinase 4) 100ug　I8600-17C

特徴

• (IRAKs) are important mediators in the signal transduction of the Toll/IL-1 receptor (TIR) family.
• Members of the TIL family play a role in innate immune responses by coordinating host defense mechanisms.
• IRAK4 is the most recently discovered IRAK protein.
• IRAK-4 has been shown to interact with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 has been shown to activate NFkB as well as mitogen-activated protein (MAP) kinase pathways.
• Studies demonstrate that mice lacking IRAK4 are severely impaired in their IL-1, Toll-like receptor (TLR) signaling and response to viral and bacterial challenges; this indicates that IRAK4 has an important role in innate immunity.
• Humans lacking IRAK 4 exhibit pyogenic bacterial infections, while their blood and fibroblast cells fail to activate NF-kB.
• IRAK-4 is believed to be required for the LPS-induced activation of antigen-presenting cells.
• Applications:Suitable for use in Western Blot and Immunofluorescence.
• Other applications have not been tested.
• Recommended Dilutions:Western Blot: 1-3ug/mlImmunofluorescence: 10ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.