84-1074-88　Bone Morphogenic Protein Receptor 1A (CD292, BMPR-1A, Bone Morphogenetic Protein Receptor Type IA, Serine Threonine Protein Kinase Receptor R5, SKR5, Activin Receptor-like Kinase 3, ALK-3, ACVRLK3) 100ug　B2553-60

特徴

• Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily of cytokines that affect bone and cartilage formation1.
• Mature BMPs are 30-38kD proteins that assume a TGF beta-like cysteine knot configuration1.
• Most BMPs are homodimers, but bioactive natural heterodimers have also been reported1.
• BMPs are involved in embryogenesis andmorphogenesis of various tissues and organs.
• They create an environment conducive for bone marrow development by stimulating the production of specific bone matrix proteins and altering stromal cell and osteoclast proliferation.
• BMPs also regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of mesenchymal cells, epithelial cells,hematopoietic cells, and neuronal cells, and are responsible for normal dorsal/ventral patterning.
• Two type I receptors have been characterized, BMPR-IA (also designated activin receptor-like kinase ALK-3, BRK-1 and SKR5), and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7)2-5.
• Type I receptors involved in BMP signaling can independently bind thevarious BMP family proteins in the absence of type II receptors.
• BMPR-IA and BMPR-IB are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion 2,6.
• Applications:Suitable for use in Western Blot, Immunoprecipitation, Immunocytochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 2ug/mlImmunofluorescence (IC): 2ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.