84-1066-43　PRG3 (p53-Responsive Gene 3) 100ug　P8930

特徴

• The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses.
• PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells.
• PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF.
• Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis.
• The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
• Applications:Suitable for use in Western Blot.
• Other applications have not been tested.
• Recommended Dilution:Western Blot: 1:500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
• Store at -20°C or colder.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.