84-1064-13 PAK1 (p21 GTPase activated protein kinase 1) 200ug P2488-01A
特徴
- Human p21-GTPase activated protein kinase 1 (PAK1) is a functional homolog of STE20 of Saccharomyces cerevisiae.
- PAK1 is a downstream effector of the Rho-family small GTPases Rac and Cdc42.
- A serine/threonine kinase, PAK1 induces the formation of filopodia and lamellipodia in Swiss 3T3 cells.
- PAK1 inhibits myosin light chain kinase, and appears to play a role in the regulation of apoptosis by phosphorylating the death against Bad.
- Membrane targeting of PAK1 induces neurite outgrowth.
- PAK1 may also regulate NF-kB activation.
- Applications:Suitable for use in Western Blot and Immunoprecipitation.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:5000Optimal dilutions to be determined by the researcher.
- Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
- Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C.
- Reconstituted product is stable for 12 months at -20°C.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Further dilutions can be made in assay buffer.
仕様
- Size：200ug
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by Protein A affinity chromatography.
- Form：Supplied as a lyophilized powder in 0.09% sodium azide.
- Specificity：Reacts with PAK1.
- Isotype：IgG
- Calc Applications Abbrev：IP WB
- Calc Crossreactivity：Hu
- Immunogen：E. coli-expressed human PAK1 (aa 333-545)
- Shelf Life：1year
- EU Commodity Code：30021010
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