Kaposi's sarcoma-associated Herpes virus (KSHV, or human Herpes virus 8, HHV8), is a gamma Herpes virus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains.
This GPCR has been shown to bind a number of chemokines including IL-8, NAP-2, PF-4, MGSA/Groa, I-309, RANTES, MCP-1, and MIP-1b.
The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation.
KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression.
IP-10, a chemokine, can inhibit constitutively activated KSHV GPCR.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide and 40% glycerol.
Specificity：Recognizes human KSHV GPCR. Reacts with KSHV GPCR expressed in transfected cells by flow cytometry.
Isotype：IgG
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：E. coli-expressed KSHV GPCR N-terminal fragment (aa1-41).
