84-1063-61　C3a Receptor 200ug　C0010-17

特徴

• C3a is an anaphylatoxin generated through activation of the complement C3.
• C3a is a potent chemoattractant for phagocytes, and it stimulates chemotaxis and other leukocyte functions.
• C3a binds to eosinophils, basophils, neutrophils, and differentiated U937 cells, that all express receptors for C3a on their cell surface.
• The C3a receptor has been cloned and shown to be a G protein-coupled receptor with seven putative transmembrane domains1,2.
• This receptor is characterized for its large extracellular loop between the fourth and fifth transmembrane domains3.
• The loop can be readily detected using the rabbit anti-C3a receptor antibody.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: recognizes C3a receptor expressed in leukocytes and in transfected cells
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
• Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.