VIP is localized in nerve fibers of the central and peripheral nervous system, and is probably acting as a neurotransmitter.
Smooth muscle relaxation, vasodilation and secretion from exocrine glands are some of the effects of VIP.
The Verner-Morrison or Watery Diarrhea Hypokaliemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors.
These VIP-producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.
Applications:Suitable for use in Immunofluorescence and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Immunofluorescence: 1:1000-1:2000 with overnight incubation at 4°CImmunohistochemistry: Frozen and paraffin sectionsOptimal dilutions to be determined by the researcher.
Positive Control:Stefanini-fixed frozen sections of rat intestine.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：50ul
Host：guinea pig
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O. Further dilutions can be made in PBS, 1% BSA, 0.09% sodium azide.
Specificity：Recognizes human VIP. Absorption with 10-100ug immunogen/ml diluted antiserum abolishes the staining, while PHI does not. Species Crossreactivity: porcine, feline, rabbit, rat, guinea pig.
