Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut.
It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions.
Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure.
Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (frozen and paraffin-embedded tissue, no proteolytic treatment required): 1:400-1:800 using PAP, with overnight incubation at 2-8°C
Optimal dilution determined by the researcher.
Positive Control:Frozen sections of rat colon.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Grade：Serum
Purity：Serum
Form：Supplied as a liquid.
Specificity：Recognizes Substance P. Species Crossreactivity: Human and rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic Substance P 4-11, conjugated to thyroglobulin using CDI.
