Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3).
These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5).
TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues (6).
Most recently genetic variation in TLR10 has been associated with contributing to asthma risk (7).
It should be noted that TLR10 exists in mice only as a pseudogene (8).
Applications:Can be used for detection of TLR10 by Western blot at 0.5 to 1ug/ml.
Despite its predicted size of ~90kD, a band correpsonding to TLR10 is observed at ~75kD in immunoblot assays.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
Store at -20°C or colder.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Highly Purified
Purity：Purified by Ion Exchange Chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Specificity：Recognizes human TLR10 (IN).
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Peptide corresponding to 14 amino acids near the middle of human TLR10 (GenBank accession no. AAQ88667)
