Members in the TNF superfamily regulate immune responses and induce apoptosis.
Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL- 2, respectively, (3,5).
BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2).
April regulates immunological and non-immunological cell growth.
Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified (6,7).
TACI, like BCMA, binds BAFF and April.
TACI and its ligands regulate humoral immune responses, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
SOURCE: Rabbit anti-TACI polyclonal antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI (8).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 2-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Specificity：Recognizes human TACI.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to a region within the N-terminus of human TACI.
