84-1061-57　Bcl 2 (B Cell Leukemia 2) 100ug　B0807-05F

特徴

• Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.
• Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1).
• Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis (reviewed in 2 and 3).
• These can be divided into two classes: those that inhibit apoptosis and those that promote cell death.
• Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis (4).
• It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad (5 for review).
• Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer (4,6).
• Applications:Can be used for detection of Bcl-2 by Western blot at 2ug/ml.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
• Store at -20°C or colder.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.