Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.
This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.
This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
Applications:Suitable for use in ELISA, Immunohistochemistry, Western Blot and Immunocytochemistry/Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000ELISA: 1:100-1:2000Immunocytochemistry (IC-IF): 1:50-1:100Immunohistochemistry (paraffin): 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human Notch 4
Isotype：IgG
Calc Applications Abbrev：E IC IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to a C-terminal portion of human Notch4 (between aa1900-2003)
