Cytonectin is a novel 35,000 molecular weight protein that displays remarkable ion-independent adherence properties.
This consigns it to a family of well-known adherence molecules essential for cell communication and the development of 3-dimensional tissue structures.
Cytonectin is expressed in a variety of organs and tissues, being evolutionarily conserved from human to avian species.
It is hypothesized to act as a "do not attack" signal molecule that prevents tissue destruction by cells of momocyte lineage.
The protein is overexpressed in Alzheimer disease entorhinal cortex as compared to normal age-matched controls.
It is also detected in tissues from patients with Down syndrome and leukemia.
Its presence in all 3 of these related conditions may prove important to their etiopathogensis.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000.
The bound primary antibody is detected by HRP-goat anti-chicken IgY Fc fragment as secondary antibody, followed by any chemiluminescence protocol
Immunohistochemistry: Most tissues have some cytonectin detectable.
Many pathologic tissues, especially neoplastic cells, show increased cytonectin expression.
The antigens are highly evolutionarily conserved in human, rodent, and avian tissues
Optimum dilutions to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：5mg
Host：chicken
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
Specificity：Recognizes human Cytonectin.
Isotype：IgY
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Purified Cytonectin was isolated from a cell lysate of normal human third trimester placenta.
