MAS1 oncogene (Proto-oncogene Mas, MAS1) is a GTP binding protein coupled receptor which shares a conserved structural motif with other proteins of its class.
When activated, MAS1 is a modulator of a critical step in the growth-regulating pathway to trigger oncogenes (PMID: 20674894).
Evidence has shown that the MAS1 oncogene acts as a receptor for angiotensin (Ang)-(1-7), however it is not fully known how Intracellular signaling through Mas1 occurs (PMID: 19461648).
Furthermore, research proves that in tandom with Ang-(1-7), the MAS1 receptor is expressed in the ovarian stroma of post menopausal women and in male testis (PMID: 20674894, 20361351).
Additionally, together with Ang- (1-7) MAS1 may be an important component of normal spermatogenesis as low expression levels were found in infertile men with impaired spermatogenesis (PMID: 20361351)
Applications:Suitable for use in Immunohistochemistry, Flow Cytometry, and Immunocytochemistry/Immunofluorescence.
Other applications not tested.
Recommended Dilutions:Immunofluorescence (IF-IC): 1:10-1:500Immunohistochemistry (frozen): 1:100-1:500Immunohistochemistry (paraffin): 1:100-1:500, prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommendedOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.01% sodium azide.
Specificity：Recognizes human Mas. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：FC IC IF IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：KLH conjugated synthetic peptide mapping to the C-terminus of human MAS1.
