GPR119 is an Orphan-U GPCR with an unknown ligand.
The G-protein-coupled receptor 119 is important in type II diabetes.
It is expressed primarily in the pancreas and gastrointestinal tract.
When GPR119 is activated in gut cells, it leads to insulin secretion from pancreatic beta cells.
This insulin secretion is glucose-dependent and leads to the release of GLP1, GIP, and PYY, which are known to help regulate the diabetic response to dietary effects.
GPR119 also is important in gut inflammation pathways.
Applications:Suitable for use in Immunohistochemistry and Immunofluorescence/Immunocytochemistry.
Antigen retrieval with sodium citrate buffer (pH 6.0) is recommended
Immunofluorescence (IF-IC): 1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 30% glycerol.
Specificity：Recognizes human GPCR119. Species Crossreactivity: mouse.
Isotype：IgG
Calc Applications Abbrev：IC IF IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide made to an internal region of the human GPR119 (within residues 150-250).Cellular Localization: Cell membrane; Multi-pass membrane protein. Species sequence homology: rat (88%)
