Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes.
Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation.
Chemokines act through seven transmembrane G protein-coupled receptors.
The chemokine system is increasingly recognized to play an important role in lymphocyte biology.
Application(s):ELISA: 1:50,000 Western Blotting: 1:1,000 Immunohistochemistry: 1:300
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide before the addition of 40% glycerol.
Specificity：Peptide sequence is < 50% identical to other human chemokine receptors in this region. Not tested for crossreactivity to mouse CxCR4 receptor. Crossreacts with human.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to N-terminal extracellular domain of human CxCR4 receptor.
