Mre11 in yeast belongs to RAD50 epistasis group gene, Mre11, blocks meiotic recombination and play roles in non-homologous end-joining (NHEJ) DNA double-strand break (DSB) repair pathways.
Human Mre11 shares approximately 50% identity at the amino acid level with its yeast counterpart in the N-terminal half of the protein (1).
Repair of DNA double-strand breaks by radiation is dependent on a multifunctional complex containing Rad50, Mre11, and the NBS1 gene product, p95 (NBS protein, nibrin) (2).
In addition function of Mre11 is also linked to ataxia telangiectasia mutated (ATM) protein kinase (3), TTAGGG repeat binding factor2 (TRF2) (4), and Ku70 (5).
A mutation of the hMre11 gene may be important in a new ataxia telangiectasia-like disorder (ATLD) (6).
Mre11 is expressed at the highest levels in proliferating tissues.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
Freeze at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, 0.02 % sodium azide.
