84-1058-29　CCR4 (CC chemokine receptor type 4, CCCKR4, CCR4, ChemR13, CKR4, CMKBR4, HGCN 14099, K5 5, MGC88293) 100ug　C2099-93

特徴

• Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes.
• Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation.
• Chemokines act through seven transmembrane G protein-coupled receptors.
• The chemokine system is increasingly recognized to play an important role in lymphocyte biology.
• CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells.
• In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement.
• Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/ml In Daudi cell lysate, a band at 42kD should be detected.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
• Freeze at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.