84-1057-83　Neurokinin B Receptor (NK-3 Receptor) 150ul　N2171-60

特徴

• The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission.
• The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors.
• Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
• Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively.
• All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g.
• G-protein coupled activation of phospholipase C).
• Applications:Suitable for use in Immunohistochemistry and Immunofluorescence.
• Not suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Immunofluorescence (IC): 1:10-1:2000Immunohistochemistry (Frozen): 1:10-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.