Plasminogen is a key proenzyme of plasmin in the fibrinolytic and thrombolytic systems, the deficiency of which leads to a mild thrombotic tendency.
Plasminogen binds to fibrin as well as to the surface of endothelial cells and monocytes/ macrophages, where it is activated to plasmin.
Apolipoprotein(a) [apo(a)] is a protein component of lipoprotein(a), high plasma levels of which constitute a risk factor for atherosclerotic thromboembolic disease.
Since apo(a) is very similar to plasminogen in terms of amino acid sequence, it inhibits plasmin generation by competing with plasminogen’s binding to fibrin and endothelial cells.
Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders.
Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots.
The carboxyl-terminal domain of streptokinase, which binds near the activation loop of plasminogen, is likely responsible for the contact activation of plasminogen in the complex.
Plasminogen related growth factors are potent effectors of growth, movement, and differentiation of epithelia and endothelia.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended DIlutions:ELISA: 1:10,000-1:100,000Western Blot: 1:1000Optimum dilutions to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1mg
Host：rabbit
Source Antibody：mouse
Grade：Highly Purified
Purity：≥98% by SDS-PAGE
Form：Supplied as a liquid in PBS, 1mM EDTA, pH 6.6
