Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1).
The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4).
PAI-1 is activated by the glycoprotein vitronectin.
Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5).
This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).
Solubility:<10mg/ml
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:10,000 to 1:100,000Optimum dilutions to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
