Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1).
The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4).
PAI-1 is activated by the glycoprotein vitronectin.
Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5).
This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).
Applications:Suitable for use in ELISA and Western Blot.
Other applications have not been tested.
Recommended Dilutions:ELISA: 1:10,000-1:100,000Western Blot: 1:1000 -1:10,000Optimum dilutions to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1ml
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid in PBS, pH 6.6, 1mM EDTA.
