13(S)-HODE (13(S)-hydroxyoctadecadienoic acid) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells.
The biological effects of 13(S)-HODE include inhibition of tumor cell adhesion to the endothelium at concentrations around 1uM (refs 1 and 2) and down regulation of IRGpIIb/IIIa receptor expression (ref 3).
13(S)-HODE methyl ester is a neutral, more lipophilic form of the free acid that can been used as an analytical standard for 13(S)-HODE.
Applications:Suitable for use in RIA and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:RIA: 2ug/wellOptimum dilutions to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
