84-1053-26　Protein S 1mg　P9108-06

特徴

• Protein S is a vitamin K-dependent, potent neutral anticoagulant plasma glycoprotein.
• Protein S has a molecular weight of approximately 70kD and concists of a single polypeptide chain.
• The concentration of protein S in human plasma is 25ug/ml, with a half-life of approximately two days.
• About 40% of Protein S in plasma is in a free form, whereas 60% is complexed with C4b-binding Protein (C4BP).
• Only the free Protein S functions as a cofactor to antigen presenting cells (APC) in the APC-dependent degradation of Factor Va and Factor VIIIa.
• Protein S is thought to function in both the coagulation and complement cascades.
• It has been suggested that g-carboxyglutamic acid (gla) dependent binding of protein S to negatively charged phospholipids may function to concentrate C4BP at cell surfaces following injury.
• The domain structure of Protein S is similar to that of the other vitamin K-dependant coagulation factors with the exception that Protein S does not possess the catalytic triad.
• Protein S is a single chain protein containing 10 gla residues in the NH2-terminal domain and 4 epidermal growth factor (EGF) domains.
• Applications:Suitable for use ELISA and Immunoelectrophoresis.
• Other applications not tested.
• Recommended Dilutions: Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.