84-1052-59　Factor V 10mg　F0011-18A

特徴

• Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320kD) that is produced in the liver.
• The gene that encodes factor V (F.V) is located on chromosome.
• A congenital deficiency of F.V is a hemorrhagic disorder inherited as an autosomal recessive disease.
• The concentration of F.V in plasma is typically 10ug/ml.
• F.V is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface.
• Other physiologic activators of F.V include plasmin, neutrophil elastase and platelet calpain.
• The activated cofactor (F.Va) is an essential component of the prothrombin activator complex, which consists of F.Va, activated factor X, calcium and anionic phospholipid surface.
• The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone.
• In a positive feedback loop, the thrombin generated accelerates its own generation by activating more F.V to F.Va.
• Thrombin also acts to down-regulate F.Va indirectly by activating Protein C, which inactivates F.Va cofactor activity.
• Application:Suitable for use in ELISA and Immunoelectrophoresis.
• Other applications not tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.