Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors.
Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors.
Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins.
Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：150ul
Host：rabbit
Source Antibody：mouse
Grade：Serum
Purity：Serum
Form：Supplied as a liquid (whole antiserum) containing 0.05% sodium azide.
Specificity：Recognizes mouse JAK3, Mr 125kD and JAK3 degradation products, Mr 95-120kD. No reaction was noted with immunoprecipitated mouse JAK1 and JAK2. Does not react with human JAK3.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo
Immunogen：Synthetic peptide corresponding to residues 934-952 (RDELCVAGAQLYACQDPAI) of mouse JAK3.
