Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel.
The classification of glutamate receptors is based on their activation by different pharmacologic agonists.
This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
The working dilution should be based on the tissue and the expected phosphorylation state
Optimal dilutions to be determined by the researcher.
Positive Control:Hippocampal neurons, rat brain tissue lysates or mouse brain tissue lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：150ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Specificity：Recognizes Glutamate Receptor 1, phosphoSer831. The antibody recognizes a protein of ~100kD corresponding to GluR1 phosphorylated at Ser831 in rat hippocampal homogenate. Immunolabeling of the GluR1 protein is blocked by the immunogen peptide but not by the corresponding non-phosphopeptide.
Isotype：IgG
Calc Applications Abbrev：DB WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to amino acids surrounding the phosphoSer831 of rat GluR1. Species sequence homology: human and mouse (100%)
