84-1048-97　Taste Receptor 2 (TR2) 100ug　T1024-03B

特徴

• Higher vertebrates are believed to possess at least five basic tastes: Sweet, bitter, sour, salty, and unami (the taste of monosodium glutamate).
• Taste receptor cells that may selectively reside in various parts of the tongue and respond to different tastants and perceive these taste modalities.
• Circumvallate papillae, found at the very back of the tongue, are particularly sensitive to biter substances.
• Foliate papillae, found at the posterior lateral edge of the tongue, are sensitive to sour and bitter.
• Fungiform papillae at the front of the tongue specialize in sweet taste
• Recently, two novel taste receptors, TR1 and TR2, have been cloned with distinct topographical distribution in taste receptor cells and taste buds.
• TRs are members of a new group of 7 TM domain containing GPCR distantly related to other chemosensory receptors (Ca+-sensing receptor (CaSR, a family of putative hormone receptor (V2R), and metabotropic glutamate receptors).
• TR1 is expressed in all fungiform taste buds, whereas TR2 localized to the circumvallate taste buds.
• Both receptors do not co-localize with gustducin.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.5-1ug/ml using control peptide to coat plates at 5-10ug/ml for T1024-03B (affinity purified) or 1ul for T1024-03A (antiserum)
• Optimal dilutions to be determined by the researcher.
• Control Peptide: T1024-03 Taste Receptor 2, Rat Control Peptide (TR2) Control Peptide for T1024-03A (antiserum) and T1024-03B (affinity purified)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.