84-1048-46　Resistin-like Molecule, alpha (RELMa) 100ug　R1587-02

特徴

• Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes.
• There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese.
• Thiozolidinediones (TZDs), a new class of anti-diabetic drugs, enhances target-tissue sensitivity to insulin.
• A screen of genes down regulated by TZD in adipocyte led to the discovery of a new protein hormone called resistin (for resistance to insulin).
• Resistin, specifically produced and secreted by adipocyte, is present at elevated levels in the blood of obese animals, and is down regulated by fasting and anti-diabetic drugs.
• Antibody to resistin stimulated glucose uptake and improved insulin sensitivity in obese mice.
• Some other protein related to resistin has been called resistin-related molecules (RELM-alpha and beta).
• Resistin family of proteins was also identified as proteins (FIZZ1-3, for Found in Inflammatory zone) involved in allergy and inflammation.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1-5ug/ml using ECLELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
• Optimal dilutions to be determined by the researcher.
• Control Peptide:R1587-05: Resistin-like Molecule, alpha, Human, Control Peptide (RELMa)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.