84-1047-75　OAT 4 (Organic anion transporter 4) 100ul　O3003-31

特徴

• Mammalian kidney and liver are critical in maintaining physiological ionic environment.
• Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion." Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway and placenta.
• Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3), have been cloned and characterized from various tissues.
• OATPs family of proteins are very similar in sequence and secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus)
• Most recently, a novel member of the OAT family, OAT4, has been cloned and characterized.
• OAT4 (human 550aa) is ~38-44% identical to other OATs.
• It is prominently expressed in the kidney and placenta.
• OAT4 interacted with chemically heterogeneous anionic compounds (nonsteroidal antiinflammatory drugs, diuretics, sulfobromopthalein, penicillin G, and bile acid salts).
• OAT4 may help in eliminating harmful anionic substances and protect the fetus.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:5000ELISA: 1:10,000-50,000 Control peptide can be used to coat plates at 1ug/ml
• Optimal dilutions to be determined by the researcher.
• Control Peptide: O3003-30
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.