84-1046-20　Metal Transporter Protein (MTP1) 100ul　M4695-50

特徴

• A novel iron-regulated gene that is homologous to the DMAT1, termed Metal Transporter Protein (MTP1, human 571aa, mouse 570aa; ~90% similarity), has been identified.
• MTP1 is also described as iron-regulated transporter (IREG1), Ferroportin1 and SLC11A3 iron transporter or solute carrier family 11 (proton coupled divalent metal ion transporter), Member 3, formerly SLC11A3).
• MTP1 contains IRE in the 5’-UTR.
• It is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial system, the duodenum and the pregnant uterus.
• MTP1 is also expressed in muscle and central nervous system cells in the embryo.
• In the adult mouse, MTP1 expression in the liver and duodenum are reciprocally regulated.
• Iron deficiency induces MTP1 expression in the duodenum but down-regulates expression in the liver.
• Therefore, MTP1 appears to be an iron-regulated protein that is involved in iron metabolism.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000-1:5000 (ECL) ELISA: 1:10,000-1: 50,000.
• Coat with 1ug/ml Control Peptide
• Optimal dilutions to be determined by the researcher.
• Recommended Control Peptide:M4695-50A: Metal Transporter Protein, Mouse, Control Peptide (MTP1)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.