Melanocortins are regulatory peptides formed by post- translational processing of pro-opiomelanocortin.
Melanocortin peptides have been suggested to perform a variety of physiological roles ranging from control of behavior, memory, neurotrophic properties, antipyretic and modulation of immune system, etc.
Their binding sites have been found distributed in tissues ranging from lachrymal and submandibular glands, pancreas, adipose tissue, bladder, duodenum, spleen, brain, gonadal tissues and malignant melanoma tumors.
Melanocyte Stimulating Hormone Receptor (MSH-R), also called Melanotropin Receptor, or Melanocortin-1 Receptor (MC1-R), is a 315 amino acid transmembrane protein belonging to the family 1 of G-Protein coupled receptors.
It is a receptor for MSH (a,b,g) and ACTH.
Its activity is mediated by G-proteins which activate adenylate cyclase.
It is found in Melanocytes and corticoaderenal tissue as well as various tissues like adrenal gland, leukocytes, lung, lymph node, ovary, testis, pituitary, placenta, spleen and uterus.
Applications:Suitable for use in ELISA.
Western Blot, though not tested, may potentially be used as an application.
Other applications not tested.
Recommended Dilutions:Western Blot: 1-10ug/ml using ECL
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Optimal dilutions to be determined by the researcher.
Control Peptide:M2868-05: Melanocortin Receptor 1, Control Peptide Mouse
Storage and Stability:May be stored at 4°C for short-te rm only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.
Immunogen：Synthetic peptide corresponding to 21aa near the C-terminus of mouse MC1-R , conjugated to KLH. Cellular localization: Cytoplasmic Domain. Species Sequence Homology: human; 70%, equine, bovine, sheep; 66% and canine; 60%.
