84-1040-79　Aquaporin 8 100ul　A3000-36A

特徴

• Water is a critical component of all living cells.
• Interestingly, tissue membranes show a great degree of water permeability.
• Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water.
• Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein “aquaporin”
• A new water channel, AQP8, has been identified in rat pancreas and testis by homology cloning.
• AQP8 (263aa; 28kD) is also found in liver, colon and salivary glands.
• AQP8 is expressed in all stages of spermatogenesis.
• Unlike other AQP, AQP8 has unusually long N-terminus and a short C-terminus.
• AQP families of proteins are predicted to contain six transmembrane domains.
• The N and C-terminus are predicted to be cytoplasmic.
• AQP8 has significant homology to various AQPs: g-TIP (plant water channel, 37%); AQP2 and MIP (37%), AQP1, AQP4, and AQP5 (30-34%); AQP3 (26%).
• AQP8 does not facilitate glycerol transport.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000-1:5000 using ECL
• ELISA: 1:10,000-50,000.
• Control peptide can be used to coat plates at 1ug/ml
• Optimal dilutions to be determined by the researcher.
• Control Peptide:A3000-36F: Aquaporin 8, Rat, Control Peptide (AQP8)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.