84-1040-39　Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23) 50ul　A2275-88H

特徴

• Serum amyloid P component or SAP or APCS, or PTX2 (mature chain 204 aa, chromosome 1q21-23) with which CRP has about 59% homology, is situated in the same area of chromosome 1.
• SAP is universally present in amyloid deposits, senile plaque and neurofibrially tangels in Alzheimer’s patients.
• SAP levels in CSF can be useful for assessing cognitive impairment in AD patients.
• However, SAP appeared not to be required for A-beta deposition since no endogenous SAP immunoreactivity was found in mice overexpressing APP.
• In mice with a targeted deletion of the SAP gene, induction of reactive amyloidosis was retarded, demonstrating the participation of SAP in pathogenesis of amyloidosis in vivo and confirming that inhibition of SAP binding to amyloid fibrils is an attractive therapeutic target.
• SAP knock out mice develop antinuclear autoimmunity and glomerulonephritis.
• However the exact role of SAP in SLE is not clear.
• SAP also neutralizes LPS and it is potentially useful in defense against serious gram-negative sepsis.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilutions:ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Recommended Control:A2275-88F: Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.