84-1039-79 STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6) 100ul S7972-42A
84-1039-79 STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6) 100ul S7972-42A
When activated by Janus kinases Stat6 is transported to the nucleus where it regulates cytokineinduced gene expression.
Required for responsiveness to IL-4 and IL-13 (1,2), Stat6 is activated via phosphorylation at tyrosine 641 (3,4).
In addition to its role in mediating IL-4 responses, Stat6 is activated in B cell lines by IFN-alpha, where it forms transcriptionally active complexes with Stat2 and p48 protein (5,6).
Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling (7).
Applications:Suitable for use in Western Blot, Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Immunoprecipitation: 1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography
Form：Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol
Specificity：Detects endogenous levels of total Stat6. Species Crossreactivity: human, mouse and rat
Isotype：IgG
Calc Applications Abbrev：IP WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide (KLH coupled) corresponding to residues surrounding amino acid 620 of human Stat6
