84-1039-76　ROR1 100ul　R2999-60

特徴

• ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors.
• They are characterized by the presence of extracellular Frizzled-like cysteine-rich domains and membrane-proximal Kringle domains, both of which are assumed to mediate protein-protein interactions.
• The ROR family RTKs are evolutionarily conserved among Caenorhabditis elegans, Drosophila, mice and humans.
• Although the functions of ROR kinases are unknown, similarities between ROR and MuSK and Trk kinases have led to speculation that ROR kinases regulate synaptic development.
• It was shown that CAM-1, a C.
• elegans ortholog of the ROR family RTKs plays several important roles in regulating cellular migration, polarity of asymmetric cell divisions, and axonal outgrowth of neurons during nematode development.
• mROR1 and mROR2 may play differential roles during the development of the nervous system.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000.
• Incubate membrane with diluted antibody in 1X TBS, 5% BSA, 0.1% Tween-20 at 4°C with gentle shaking overnight.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.